1: With water; acetic acid in acetonitrile T=80°C; 17 h; 2: With water; lithium hydroxide hydrate T=70°C; 17 h; chemoselective reaction;

water; acetic acid in acetonitrile T=80°C; 17 h; chemoselective reaction;

Stage #1: With  lithium trifluoromethane sulfonate in  N,N-dimethyl-formamide T=0°C; 0.5 h;  Molecular sieveInert atmosphere; Stage #2: With  rubidium iodide in  N,N-dimethyl-formamide T=0°C;  Inert atmosphere; Stage #3: With  1,8-diazabicyclo[5.4.0]undec-7-ene in  N,N-dimethyl-formamide T=0 - 20°C;  Inert atmosphere;  chemoselective reaction;