您好，欢迎来到魔法化学网！
合作交流
|
服务时间(9:30-18:00)
百科
百科
▼
百科
资讯
搜索
结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
首页
化合物百科
价格行情
资讯
化工导航
实验室工具
搜索
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1086062-75-0
合成路线
（共 7 条）
65340-70-7
4-氯-6-溴喹啉
→
反应条件
1086062-75-0
反应条件
hydrogenchloride in tetrahydrofuran; diethyl ether T=20°C; 0.5 h;
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
Location in patent: Paragraph 0156; 0157 ;
187278-01-9
5-[(4-溴苯基氨基)亚甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮
→
反应条件
1086062-75-0
反应条件
1: diphenylether / 0.25 h / 245 - 250 °C / Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 3: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C View Scheme
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
145369-94-4
6-溴-4-羟基喹啉
→
反应条件
1086062-75-0
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 2: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C View Scheme
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
106-40-1
对溴苯胺
→
反应条件
1086062-75-0
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione / ethanol / 4 h / 85 °C 2: 1,2-dichloro-benzene / 6.5 h / 0 - 188 °C 3: trichlorophosphate / toluene / 4 h / 115 °C 4: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C View Scheme
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
1086062-75-0
→
反应条件
1086063-18-4
6-溴-4-(吡嗪-4-基)喹啉
反应条件
1: sodium iodide / anhydrous propionitrile / 96 h / Reflux 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
1086062-75-0
→
反应条件
927801-23-8
6-溴-4-碘-喹啉
反应条件
sodium iodide in anhydrous propionitrile 96 h; Reflux;
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
1086062-75-0
→
反应条件
1086062-66-9
2,4-二氟-n-[2-甲氧基-5-[4-(4-吡嗪)-6-喹啉]-3-吡啶]苯磺酰胺
反应条件
1: sodium iodide / anhydrous propionitrile / 96 h / Reflux 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux 3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / 1,4-dioxane / Reflux 4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / 1,4-dioxane / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
