6-溴-4-(吡嗪-4-基)喹啉合成路线 （共 7 条）
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane Reflux;
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
1: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C 2: sodium iodide / anhydrous propionitrile / 96 h / Reflux 3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
1: sodium iodide / anhydrous propionitrile / 96 h / Reflux 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 2: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C 3: sodium iodide / anhydrous propionitrile / 96 h / Reflux 4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
1: diphenylether / 0.25 h / 245 - 250 °C / Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 3: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C 4: sodium iodide / anhydrous propionitrile / 96 h / Reflux 5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
potassium acetate; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane in 1,4-dioxane T=100°C; 3 h;
参考文献
US2013/317037 A1, ;
Paragraph 0104 ;
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / 1,4-dioxane / Reflux 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / 1,4-dioxane / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
