N-bromosuccinmide; sodium hydroxide in N,N-dimethyl-formamide T=20°C; 1 h; Reagent/catalystSolventTemperature;

1: sulfuric acid / 60 °C / |Inert atmosphere 2: sodium hydroxide; N-bromosuccinmide / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C / |Inert atmosphere 1.2: 1 h / 20 °C / |Inert atmosphere 2.1: caesium carbonate / water; toluene / 0.5 h / |Inert atmosphere; |Sealed tube 2.2: 4 h / 120 °C / |Inert atmosphere; |Sealed tube 3.1: lithium hydroxide hydrate / 1,4-dioxane; methanol; water / |Heating 4.1: hydrogen; palladium 10 on activated carbon / methanol; ethyl acetate / 12 h / 20 °C / |Inert atmosphere View Scheme