2-甲基吡咯烷-1,2-二羧酸-1-苄酯合成路线 （共 7 条）
反应条件
1: With diisobutylaluminium hydride in dichloromethane; toluene T=-70°C; 2 h; 2: With hydrogenchloride in dichloromethane; water; toluene T=-70 - 20°C;
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1400518 A1, 2004 ;
Location in patent: Page 22 ;
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=-75 - -20°C; 4 h;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Virajkumar B.; Penning, Thomas D.; Giranda, Vincent L.
Patent: US2006/229289 A1, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
1: 46 percent / Candida antarctica lipase / aq. phosphate buffer / 38 h / 30 °C 2: 97 percent / NaBH4; LiCl View Scheme
参考文献
Kurokawa, Masayuki; Shindo, Takeyuki; Suzuki, Masumi; Nakajima, Nobuyoshi; Ishihara, Kohji; Sugai, Takeshi
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1323 - 1333
反应条件
1: 46 percent / Candida antarctica lipase / aq. phosphate buffer / 38 h / 30 °C View Scheme
参考文献
Kurokawa, Masayuki; Shindo, Takeyuki; Suzuki, Masumi; Nakajima, Nobuyoshi; Ishihara, Kohji; Sugai, Takeshi
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1323 - 1333
反应条件
Candida antarctica lipase in phosphate buffer T=30°C; 38 h;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 10 p. 1323 - 1333
反应条件
triethylsilane; palladium diacetate; triethylamine in ethanol 15 h; Ambient temperature;
参考文献
Sakaitani, Masahiro; Hori, Keiko; Ohfune, Yasufumi
Tetrahedron Letters, 1988 , vol. 29, # 24 p. 2983 - 2984
反应条件
1: With diethylaluminium chloride in hexane; dichloromethane
T=0°C; 1 h;
2: With methyl-phenyl-thioether in hexane; dichloromethane
T=25°C; 5 h;
参考文献
Tsujimoto, Takashi; Murai, Akio
Synlett, 2002 , # 8 p. 1283 - 1284
