1-苄基-4-苯基-1,2,3-噻唑合成路线 （共 52 条）
反应条件
sodium azide in ethanol; water
T=90°C; 15 h; Inert atmosphere;
参考文献
Beneteau, Valerie; Olmos, Andrea; Boningari, Thirupathi; Sommer, Jean; Pale, Patrick
Tetrahedron Letters, 2010 , vol. 51, # 28 p. 3673 - 3677
反应条件
in water
T=70°C; Huisgen Cycloaddition; 12 h; Green chemistry;
参考文献
Radatz, Catia Schwartz; Soares, Liliana Do Amaral; Vieira, Estefano Roberto; Alves, Diego; Russowsky, Dennis; Schneider, Paulo Henrique
New Journal of Chemistry, 2014 , vol. 38, # 4 p. 1410 - 1417
反应条件
1: N-iodo-succinimide; silver nitrate / water; acetone / 2.5 h / 20 °C / Darkness
2: copper(l) iodide; triethyl 2,2',2''-(4,4',4''-(nitrilotris(methylene))tris(1H-1,2,3-triazole-4,1-diyl))triacetate / tetrahydrofuran / 27 h / 20 °C / Inert atmosphere; Darkness
3: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 110 °C / Inert atmosphere
View Scheme
参考文献
Juricek, Michal; Stout, Kathleen; Kouwer, Paul H. J.; Rowan, Alan E.
Organic Letters, 2011 , vol. 13, # 13 p. 3494 - 3497
反应条件
pyridine; 1,10-phenanthroline; [Cu(I)(CH3CN)4]PF6
T=20°C; 24 h; Inert atmosphereDarkness;
参考文献
Proietti Silvestri, Ilaria; Andemarian, Fikre; Khairallah, George N.; Wan Yap, Su; Quach, Tim; Tsegay, Sammi; Williams, Craig M.; O'Hair, Richard A. J.; Donnelly, Paul S.; Williams, Spencer J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 17 p. 6082 - 6088
反应条件
in toluene
T=80°C; 24 h; Inert atmosphere; Catalytic behavior; Solvent;
参考文献
Lo, Yih-Hsing; Wang, Tsang-Hsiu; Lee, Chia-Yi; Feng, Ying-Hsuan
Organometallics, 2012 , vol. 31, # 19 p. 6887 - 6899
反应条件
NiCl2((PPh3)P)2; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=60°C; Negishi Coupling;
参考文献
Stefani, Helio A.; Leal, Daiana M.; Manarin, Flavia
Tetrahedron Letters, 2012 , vol. 53, # 48 p. 6495 - 6499,5
反应条件
1: α,α-dichloroacetophenone With polystyrene-sulfonyl hydrazide resin; titanium tetrachloride in methanol; dichloromethane
T=20°C; 12 h;
2: benzylamine in methanol
T=20°C; 12 h; Further stages.;
参考文献
Raghavendra, Makam S.; Lam, Yulin
Tetrahedron Letters, 2004 , vol. 45, # 32 p. 6129 - 6132
反应条件
ammonia in ethanol; water
T=20°C; 24 h;
参考文献
Shao, Changwei; Wang, Xinyan; Xu, Jimin; Zhao, Jichen; Zhang, Qun; Hu, Yuefei
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 7002 - 7005
反应条件
copper(l) iodide; sodium azide; tetra-(n-butyl)ammonium iodide; triethylamine; 1-(toluene-p-sulphonyl)imidazole in N,N-dimethyl-formamide
参考文献
Zhang, Jian; Wu, Jingjing; Shen, Li; Jin, Guanyi; Cao, Song
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 4 p. 580 - 584
反应条件
1: CuSO4; sodium hydrogen carbonate; trifluoromethanesulfonyl azide / CH2Cl2; methanol; H2O / 0.5 h / 20 °C
2: N,N,N-tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine; sodium ascorbate / CH2Cl2; H2O; methanol / 0.5 h / 80 °C / microwave irradiation
View Scheme
参考文献
Beckmann, Henning S. G.; Wittmann, Valentin
Organic Letters, 2007 , vol. 9, # 1 p. 1 - 4
