6-甲基-3H-噻吩[2,3-D]嘧啶-4-酮合成路线 （共 5 条）
参考文献
Kaplina, N. V.; Grinev, A. N.; Bogdanova, G. A.; Alekseeva, L. M.; Pushkina, T. V.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 126 - 129
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 197 - 200
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 2 p. 305 - 308
反应条件
1: 82 percent / phosphorus oxychloride, DMF / 1,2-dichloro-ethane / 1.5 h / Heating 2: 55 percent / N-bromosuccinimide, benzoylperoxide / CCl4 / 1.5 h / Heating View Scheme
参考文献
Kaplina, N. V.; Grinev, A. N.; Bogdanova, G. A.; Alekseeva, L. M.; Pushkina, T. V.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 126 - 129
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 197 - 200
反应条件
N,N-dimethyl-formamide; trichlorophosphate in 1,2-dichloro-ethane 1.5 h; Heating;
参考文献
Kaplina, N. V.; Grinev, A. N.; Bogdanova, G. A.; Alekseeva, L. M.; Pushkina, T. V.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 126 - 129
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 197 - 200
反应条件
1: phosphorus pentachloride; trichlorophosphate
2: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Heating
View Scheme
参考文献
Golub, Andriy G.; Bdzhola, Volodymyr G.; Briukhovetska, Nadiia V.; Balanda, Anatoliy O.; Kukharenko, Olexander P.; Kotey, Igor M.; Ostrynska, Olga V.; Yarmoluk, Sergiy M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 870 - 876
