2-氨基-5-碘-3-甲基苯羧酸合成路线 （共 8 条）
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide T=75°C; 1 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 53, # 4 p. 388 - 391
参考文献
American Chemical Journal, , vol. 44, p. 124,508
反应条件
in N,N-dimethyl-formamide
T=140°C; 20 h; Inert atmosphere;
参考文献
Allendoerfer, Nadine; Es-Sayed, Mazen; Nieger, Martin; Braese, Stefan
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 388 - 391
反应条件
1: With copper(l) iodide; potassium iodide in chlorobenzene
T=20°C;
2: With N-methyl-2-(methylamino)ethylamine in chlorobenzene
T=115°C; 18 h;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2006/68669 A1, 2006 ;
Location in patent: Page/Page column 18; 27 ;
反应条件
in DMF (N,N-dimethyl-formamide)
T=140 - 145°C; 20 h;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2006/23783 A1, 2006 ;
Location in patent: Page/Page column 27 ;
反应条件
copper(l) iodide; potassium iodide; N-methyl-2-(methylamino)ethylamine in chlorobenzene
T=120°C; 24 h;
参考文献
Selby, Thomas P.; Lahm, George P.; Stevenson, Thomas M.; Hughes, Kenneth A.; Cordova, Daniel; Annan, I. Billy; Barry, James D.; Benner, Eric A.; Currie, Martin J.; Pahutski, Thomas F.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6341 - 6345
反应条件
in tetrahydrofuran
T=20°C; 4 h;
参考文献
Zhou, Yunyun; Wang, Baolei; Di, Fengjuan; Xiong, Lixia; Yang, Na; Li, Yuxin; Li, Zhengming
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2295 - 2299
反应条件
1: in tetrahydrofuran
22 h; Heating;
2: With phosphorus tribromide in diethyl ether
24 h; Heating;
参考文献
Lee, Alex H. F.; Kool, Eric T.
Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 132 - 140
