2,3,5-三氟-4-(4-甲基-1-哌嗪基)-beta-氧代-苯丙酸合成路线 （共 2 条）
反应条件
hydrogenchloride in tetrahydrofuran; diethyl ether; ethanol; nitrogen; water; toluene
参考文献
Mediolanum Farmaceutici S.p.A.
Patent: US5221741 A1, 1993 ;
反应条件
1: 91 percent / toluene / 1 h / Heating 2: 77 percent / ethanol / 5 h / Ambient temperature 3: 88 percent / NaH / tetrahydrofuran / 15 h / 0 °C 4: 86 percent / 15percent aq. NaOH / 0.25 h / Heating View Scheme
参考文献
Cecchetti; Fravolini; Schiaffella
Synthetic Communications, 1991 , vol. 21, # 22 p. 2301 - 2308
