1,3-二氧戊环-4-羧酸,2,2-二甲基-,甲酯合成路线 （共 16 条）
反应条件
N,N,N',N,-tetramethylethylenediamine in acetonitrile T=60°C; 6 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/270469 A1, 2009 ;
Location in patent: Page/Page column 30 ;
反应条件
potassium carbonate in acetone 5 h; Heating;
参考文献
Schwarz, Karl-Heinz; Kleiner, Katharina; Ludwig, Ralf; Schroetter, Eberhard; Schick, Hans
Liebigs Annalen der Chemie, 1991 , # 5 p. 503 - 504
反应条件
potassium carbonate in acetone T=65°C; 4 h;
参考文献
Gravestock, Michael B.; Knight, David W.; Lovell, Jennifer S.; Thornton, Steven R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1661 - 1664
反应条件
1: KMnO4, NaOH View Scheme
参考文献
Schwarz, Karl-Heinz; Kleiner, Katharina; Ludwig, Ralf; Schroetter, Eberhard; Schick, Hans
Liebigs Annalen der Chemie, 1991 , # 5 p. 503 - 504
反应条件
toluene-4-sulfonic acid in dichloromethane 30 h; Heating;
参考文献
Schoenecker, Bruno
Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 5/6 p. 705 - 712
反应条件
copper(II) sulfate; acetone
参考文献
Fischer; Baer
Helvetica Chimica Acta, 1933 , vol. 16, p. 534,545
反应条件
potassium hydroxide; potassium permanganate; N,N,N',N,-tetramethylethylenediamine 1.) water, 0-10 deg C, 30 min, 2.) acetonitrile, 50 deg C, 5 h; Yield given. Multistep reaction;
参考文献
Kawakami, Yuhsuke; Asai, Tamio; Umeyama, Kiyoshi; Yamashita, Yuya
Journal of Organic Chemistry, 1982 , vol. 47, # 18 p. 3581 - 3585
反应条件
in methanol; hexane; water; acetonitrile
参考文献
Yamaoka, Hidenori; Moriya, Narimasa; Ikunaka, Masaya
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 931 - 938
参考文献
Hill, Alison M.; Harris, Jonathan P.; Siskos, Alexandros P.
Chemical Communications, 1998 , # 21 p. 2361 - 2362
反应条件
in methanol; water; acetonitrile pH=4; Acidic aqueous solution;
参考文献
Nagase & Co., Ltd.; Nagase Chemtex Corporation
Patent: JP2005/75784 A, 2005 ;
Location in patent: Page/Page column 16; 22 ;
