1,3-二氧戊环-4-羧酸,2,2-二甲基-,甲酯合成路线 （共 16 条）
反应条件
sodium hydroxide; Soerensen phosphate buffer; thermitase in water T=33°C; 1.73333 h; kinetic resolution; Product distribution;
参考文献
Schick, Hans; Schroetter, Eberhard; Szymanowski, Matthias; Knoll, Alexander
Liebigs Annalen der Chemie, 1993 , # 1 p. 103 - 104
反应条件
sodium hydroxide; water; penicillin acylase T=10 - 20°C; pH=7.5; 3 - 20 h; Resolution of racemateAqueous phosphate buffer;
参考文献
ALTUS BIOLOGICS INC.
Patent: WO2004/3001 A1, 2004 ;
Location in patent: Page 11-14 ;
反应条件
sodium hydroxide; water; penicillin acylase T=20°C; pH=7.5; 2 h; Resolution of racemateAqueous phosphate buffer;
参考文献
ALTUS BIOLOGICS INC.
Patent: WO2004/3001 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
sodium hydroxide; water; penicillin acylase T=20°C; pH=7.5; 2 h; Resolution of racemateAqueous phosphate buffer;
参考文献
ALTUS BIOLOGICS INC.
Patent: WO2004/3001 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
methanol; potassium hydroxide
T=0 - 20°C; 0.75 h;
参考文献
Rosseto, Renato; Hajdu, Joseph
Tetrahedron, 2014 , vol. 70, # 19 p. 3155 - 3165
反应条件
sodium hydroxide; Soerensen phosphate buffer; thermitase in water
T=33°C; 1.73333 h; kinetic resolution; Product distribution;
参考文献
Schick, Hans; Schroetter, Eberhard; Szymanowski, Matthias; Knoll, Alexander
Liebigs Annalen der Chemie, 1993 , # 1 p. 103 - 104
