5-甲基-2-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)苯甲酸甲酯合成路线 （共 8 条）
反应条件
triethylamine; palladium diacetate; tris-(o-tolyl)phosphine in 2-methyl tetrahydrofuran T=11.5 - 77°C; 1.5 h;
参考文献
Girardin, Melina; Ouellet, Stephane G.; Gauvreau, Danny; Moore, Jeffrey C.; Hughes, Greg; Devine, Paul N.; O'Shea, Paul D.; Campeau, Louis-Charles
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 61 - 68
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=100°C; 3 h; Inert atmosphereSealed tube;
参考文献
BioChromix AB; ÅSBERG, Peter; HAMMER, Kristin; OLSSON, Johan; HENRIKSSON, Martin
Patent: WO2013/36196 A1, 2013 ;
Location in patent: Page/Page column 95-96 ;
反应条件
[Ir(OMe)(COD)]2/tris[3,5-bis(CF3)phenyl]phosphine in octane 80°C, 16 h, benzoate ester (5.0 mmol), bis(pinacolato)diboron (1.0 mmol), (Ir(OMe)(COD))2 (0.015 mmol), tris(3,5-bis(trifluoromethyl)phenyl)phosphine (0.06 mmol);
参考文献
Ishiyama, Tatsuo; Isou, Hironori; Kikuchi, Takao; Miyaura, Norio
Chemical Communications, 2010 , vol. 46, # 1 p. 159 - 161
反应条件
1: acetyl chloride / 0 - 20 °C 2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / |Inert atmosphere; |Sealed tube View Scheme
反应条件
1: sulfuric acid / methanol / 18 h / 65 °C / |Large scale 2: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / 2-methyl tetrahydrofuran / 1 h / 60 - 77 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 17, # 1 p. 61 - 68
反应条件
sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 2-methyl tetrahydrofuran; water T=24 - 74°C; 16 h;
参考文献
MERCK and CO., INC.
Patent: WO2008/147518 A1, 2008 ;
Location in patent: Page/Page column 43; 45 ;
WO 2008/147518 A1
反应条件
1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / water; 2-methyl tetrahydrofuran / 16 h / 74 °C / |Inert atmosphere; |Large scale 2: sodium hydroxide / water; 2-methyl tetrahydrofuran / 1.5 h / 72 °C / |Large scale 3: N-ethyl-N,N-diisopropylamine; 1-propanephosphonic acid cyclic anhydride / dichloromethane / 18 h / 12 - 44 °C / |Large scale View Scheme
参考文献
Girardin, Melina; Ouellet, Stephane G.; Gauvreau, Danny; Moore, Jeffrey C.; Hughes, Greg; Devine, Paul N.; O'Shea, Paul D.; Campeau, Louis-Charles
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 61 - 68
反应条件
1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / water; 2-methyl tetrahydrofuran / 16 h / 74 °C / |Inert atmosphere; |Large scale 2: sodium hydroxide / water; 2-methyl tetrahydrofuran / 1.5 h / 72 °C / |Large scale View Scheme
参考文献
Girardin, Melina; Ouellet, Stephane G.; Gauvreau, Danny; Moore, Jeffrey C.; Hughes, Greg; Devine, Paul N.; O'Shea, Paul D.; Campeau, Louis-Charles
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 61 - 68
