4-甲氧基吲哚啉-2,3-二酮合成路线 （共 5 条）
反应条件
sulfuric acid; water T=100°C; 10 h;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/110917 A2, 2006 ;
Location in patent: Page/Page column 127 ;
WO 2006/110917 A2
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Ambient temperature;
参考文献
Wierenga, Wendell; Griffin, John; Warpehoski, Martha A.
Tetrahedron Letters, 1983 , vol. 24, # 24 p. 2437 - 2440
反应条件
1: 80 percent / n-BuLi / tetrahydrofuran / 3 h / 0 °C 2: 88 percent / 12N HCl / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Hewawasam, Piyasena; Meanwell, Nicholas A.
Tetrahedron Letters, 1994 , vol. 35, # 40 p. 7303 - 7306
参考文献
Guengoer, Timur; Chen, Ying; Golla, Rajasree; Ma, Zhengping; Corte, James R.; Northrop, John P.; Bin, Bin; Dickson, John K.; Stouch, Terry; Zhou, Rong; Johnson, Susan E.; Seethala, Ramakrishna; Feyen, Jean H. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2440 - 2455
反应条件
1: With sodium hydroxide in water T=30 - 40°C; 0.5 h; 2: With sodium nitrite in water T=0°C; 0.333333 h; 3: With hydrogenchloride; sulfuric acid; tin(ll) chloride Product distribution / selectivity; more than 3 stages;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 67 ;
