N-BOC-3-碘-L-丙氨酸苄酯合成路线 （共 10 条）
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane T=0°C; 2 h; Inert atmosphere;
参考文献
Koseki, Yohei; Yamada, Haruka; Usuki, Toyonobu
Tetrahedron Asymmetry, 2011 , vol. 22, # 5 p. 580 - 586
反应条件
sodium iodide in acetone 24 h; Ambient temperature;
参考文献
Stocking, Emily M.; Schwarz, Jessie N.; Senn, Hans; Salzmann, Michael; Silks, Louis A.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 16 p. 2443 - 2447
反应条件
1: 95 percent 2: 85 percent / pyridine 3: 80 percent / NaI / acetone View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2443 - 2447
反应条件
1: 95 percent 2: 85 percent / pyridine 3: 80 percent / NaI / acetone View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2443 - 2447
反应条件
1: 74 percent / CCl4 / 8 h / Heating 2: 81 percent / 1 M NaOH / tetrahydrofuran / 1 h / Ambient temperature 3: 84 percent / pyridine / 24 h / -10 °C 4: 80 percent / NaI / acetone / 24 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 12 p. 3397 - 3404
反应条件
1: sodium hydroxide / tetrahydrofuran; water / 2 h / 20 °C / Cooling 2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2 h / 0 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 5 p. 580 - 586
反应条件
diethyl 4-phosphono(difluoromethyl)iodobenzene; zinc; bis-triphenylphosphine-palladium(II) chloride 1.) THF/N,N-dimethylacetamide, 65 deg C, 1 h, 2.) THF/N,N-dimethylacetamide, 65 deg C, 5 h; Multistep reaction. Yields of byproduct given;
参考文献
Smyth; Burke Jr.
Tetrahedron Letters, 1994 , vol. 35, # 4 p. 551 - 554
反应条件
zinc; bis-triphenylphosphine-palladium(II) chloride 1.) THF/N,N-dimethylacetamide, 65 deg C, 1 h, 2.) THF/N,N-dimethylacetamide, 65 deg C, 5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Smyth; Burke Jr.
Tetrahedron Letters, 1994 , vol. 35, # 4 p. 551 - 554
反应条件
copper; zinc; bis (triortho-tolylphosphine)palladium(II) chloride
1.) benzene/dimethylacetamide, 30 min, 22-35 deg C, 2.) 50 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Jackson, Richard F. W.; Wythes, Martin J.; Wood, Anthony
Tetrahedron Letters, 1989 , vol. 30, # 43 p. 5941 - 5944
反应条件
bis-triphenylphosphine-palladium(II) chloride; ethylene dibromide; zinc
1) THF, 1.5 h, 2) THF, benzene, 35 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Walker, Michael A.; Kaplita, Khane Pham; Chen, Ti; King, H. Dalton
Synlett, 1997 , vol. 1997, # 2 p. 169 - 170
