二乙基 3,5-二甲氧基苄基磷酸酯合成路线 （共 23 条）
反应条件
1: 92 percent / LiAlH4 / diethyl ether 2: 94 percent / PBr3 / CH2Cl2 3: 95 percent / 130 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 47, # 3 p. 167 - 174
反应条件
1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C 2: phosphorus tribromide; pyridine / dichloromethane / 4 h / 0 - 20 °C 3: 10 h / 120 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 24 p. 7683 - 7687
参考文献
Chemistry - A European Journal, , vol. 16, # 43 p. 12808 - 12813
反应条件
1.1: NaOMe; 18/6-crown ether / dimethylformamide / 0.08 h / 20 °C 1.2: 87 percent / 18/6-crown ether / dimethylformamide / 6 h / 20 - 120 °C 2.1: 93 percent / pyridinium p-toluene sulfonate / methanol / Heating View Scheme
参考文献
Lee, Iljung; Choe, Yearn Seong; Choi, Joon Young; Lee, Kyung-Han; Kim, Byung-Tae
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 883 - 892
反应条件
1: potassium hydroxide / tetrahydrofuran / 24 h / |Inert atmosphere 2: methyl iodide; magnesium / diethyl ether / 45 - 190 °C / |Inert atmosphere 3: triethylamine / dichloromethane / 4 h / |Inert atmosphere View Scheme
参考文献
Jungong, Christian S.; Novikov, Alexei V.
Synthetic Communications, 2012 , vol. 42, # 24 p. 3589 - 3597,9
Title/Abstract Full Text Show Details
Jungong, Christian S.; Novikov, Alexei V.
Synthetic Communications, 2012 , vol. 42, # 24 p. 3589 - 3597
反应条件
1: 1.7 g / sodium hydride / dimethylformamide / 20 °C 2: boron tribromide / CH2Cl2 / 3 h / 25 - 35 °C View Scheme
参考文献
Malan, Elfranco; Swinny, Ewald; Ferreira, Daneel; Hall, Alida J.
Phytochemistry (Elsevier), 1988 , vol. 27, # 7 p. 2309 - 2312
反应条件
1: diethyl (3,5-dimethoxyphenyl)methylphosphonate With sodium methylate in N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere; 2: pyridine-4-carbaldehyde in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Lu, Chuanjun; Guo, Yueyan; Li, Jianheng; Yao, Meicun; Liao, Qiongfeng; Xie, Zhiyong; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7683 - 7687
反应条件
sodium methylate in N,N-dimethyl-formamide T=100°C; Horner-Wadsworth-Emmons reaction; 1.5 h;
参考文献
Murias, Marek; Handler, Norbert; Erker, Thomas; Pleban, Karin; Ecker, Gerhard; Saiko, Philipp; Szekeres, Thomas; Jaeger, Walter
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5571 - 5578
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; Wittig-Horner reaction;
参考文献
Li, Yue-Qing; Li, Ze-Lin; Zhao, Wei-Jie; Wen, Rui-Xing; Meng, Qing-Wei; Zeng, Yi
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 9 p. 1084 - 1089
反应条件
sodium hydride in tetrahydrofuran T=0 - 20°C; Horner-Wadsworth-Emmons olefination; stereoselective reaction;
参考文献
Galindo; Hernaez; Berna; Fenoll; Cenis; Escribano; Alonso
Antiviral Research, 2011 , vol. 91, # 1 p. 57 - 63
