Boc-L-焦谷氨酸甲酯合成路线 （共 39 条）
反应条件
4-(N,N-dimethlyamino)pyridine in triethylamine; acetonitrile 3 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 50, # 21 p. 6221 - 6238
反应条件
1: methanol; (S)-(-)-2-pyrrolidone-5-carboxylic acid With thionyl chloride T=30°C; 1 h; 2: di-tert-butyl dicarbonate With 4-(N,N-dimethlyamino)pyridine; triethylamine in ethyl acetate T=30°C;
参考文献
WO2010/9014 A2, ;
Page/Page column 6 ;
WO 2010/009014 A2
反应条件
1: methanol; (S)-(-)-2-pyrrolidone-5-carboxylic acid With thionyl chloride T=10 - 30°C; 2.08333 h; 2: With triethylamine in ethyl acetate 0.5 h; 3: di-tert-butyl dicarbonate With 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20 - 30°C; 1.5 h;
参考文献
US2007/232806 A1, ;
Page/Page column 3 ;
反应条件
ruthenium(IV) oxide; sodium periodate in ethyl acetate 6 h; Ambient temperature;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 34, # 9 p. 3873 - 3878
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C;
参考文献
WO2006/125974 A1, ;
Page/Page column 58 ;
WO 2006/125974 A1
反应条件
1: Boc-pGlu-OH With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.333333 h; 2: methyl iodide in N,N-dimethyl-formamide
参考文献
US2007/37817 A1, ;
Page/Page column 27 ;
US 20070037817 A1
反应条件
1: 70 percent / SOCl2 / 2 h / 20 °C 2: 70 percent / DMAP / acetonitrile / 3 h View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 6 p. 945 - 947
反应条件
1: 100 percent / aq. NaHCO3 / methanol / 3 h / Irradiation 2: 2.73 g / DMAP / acetonitrile / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1483 - 1491
反应条件
dichloromethane; trimethylsilylazide; iodosylbenzene T=-40°C; 15 h; various quantity of reagents, further L-proline derivatives; Product distribution;
参考文献
Tetrahedron Letters, , vol. 35, # 44 p. 8097 - 8100
参考文献
Tetrahedron Letters, , vol. 49, # 27 p. 4289 - 4291
