6,7-二氢-5H-环戊二烯并[b]吡啶-3-甲腈合成路线 （共 4 条）
反应条件
catacxium A; sodium carbonate; palladium diacetate in 1-methyl-pyrrolidin-2-one T=160°C; 16 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; SIENA BIOTECH S.P.A; GABELLIERI, Emanuele; GUBA, Wolfgang; HILPERT, Hans; MAUSER, Harald; MAYWEG, Alexander V.; ROGERS-EVANS, Mark; ROMBACH, Didier; THOMAS, Andrew; WOLTERING, Thomas; WOSTL, Wolfgang
Patent: WO2012/126791 A1, 2012 ;
Location in patent: Page/Page column 73 ;
WO 2012/126791 A1
反应条件
sodium carbonate; K4[Fe(CN)6] trihydrate; di-(1-adamantyl)-n-butylphosphine in 1-methyl-pyrrolidin-2-one T=160°C; 16 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; SIENA BIOTECH S.P.A; HILPERT, Hans; NARQUIZIAN, Robert; PINARD, Emmanuel; POLARA, Alessandra; ROGERS-EVANS, Mark; WOLTERING, Thomas; WOSTL, Wolfgang
Patent: WO2012/156284 A1, 2012 ;
Location in patent: Page/Page column 127-128 ;
反应条件
1: 43 percent / PBr3 / 1.5 h / Heating 2: 73 percent / Zn-dust, acetic acid / ethanol / 0.75 h / Heating View Scheme
参考文献
Paine, John B.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 351 - 355
反应条件
1: 75 percent / NaOCH3 / diethyl ether; ethanol / standing overnight 2: 42 percent / piperidine acetate / H2O / 4 h / Heating 3: 43 percent / PBr3 / 1.5 h / Heating 4: 73 percent / Zn-dust, acetic acid / ethanol / 0.75 h / Heating View Scheme
参考文献
Paine, John B.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 351 - 355
