N-甲基哌嗪合成路线

参考文献

Helsinn Healthcare SA; Fadini, Luca; Manini, Peter; Pietra, Claudio; Giuliano, Claudio; Lovati, Emanuela; Cannella, Roberta; Venturini, Alessio; Stella, Valentino J.
Patent: US8426450 B1, 2013 ;
Location in patent: Page/Page column 25 ;

109-01-3N-甲基哌嗪

342417-01-06-(4-甲基哌嗪-1-基)-4-(2-甲基苯基)烟酰胺

参考文献

Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166

109-01-3N-甲基哌嗪

3563-46-0

参考文献

Lespagnol; Cuingnet
9. Congr. Soc. Pharm. Clermont-Ferrand, 1957 , p. 175,178

109-01-3N-甲基哌嗪+

13745-98-7

3454-96-43-氯-11-(4-甲基-1-哌嗪基)二苯并[b,f][1,4]氧氮杂卓

参考文献

Schmutz,J. et al.
Helvetica Chimica Acta, 1967 , vol. 50, p. 245 - 254

109-01-3N-甲基哌嗪+

4858-85-92,3-二氯吡嗪

313657-05-51-(3-氯-2-吡嗪)-4-甲基哌嗪

参考文献

BIOVITRUM AB
Patent: WO2004/9586 A1, 2004 ;
Location in patent: Page 54 ;
WO 2004/009586 A1

109-01-3N-甲基哌嗪+

4858-85-92,3-二氯吡嗪

313657-05-51-(3-氯-2-吡嗪)-4-甲基哌嗪

参考文献

Biovitrum AB
Patent: US6465467 B1, 2002 ;
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109-01-3N-甲基哌嗪+

6361-21-32-氯-5-硝基苯甲醛

30742-63-32-(4-甲基哌嗪)-5-硝基苯甲醛

参考文献

William, Anthony D.; Lee, Angeline C.-H.; Blanchard, Stephanie; Poulsen, Anders; Teo, Ee Ling; Nagaraj, Harish; Tan, Evelyn; Chen, Dizhong; Williams, Meredith; Sun, Eric T.; Goh, Kee Chuan; Ong, Wai Chung; Goh, Siok Kun; Hart, Stefan; Jayaraman, Ramesh; Pasha, Mohammed Khalid; Ethirajulu, Kantharaj; Wood, Jeanette M.; Dymock, Brian W.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4638 - 4658

109-01-3N-甲基哌嗪+

823-78-93-溴苄溴

331977-03-81-(3-溴苯甲基)-4-甲基哌嗪

参考文献

F. HOFFMANN-LA ROCHE AG
Patent: WO2008/28617 A1, 2008 ;
Location in patent: Page/Page column 44-45 ;
WO 2008/028617 A1

109-01-3N-甲基哌嗪+

3132-99-8

331977-03-81-(3-溴苯甲基)-4-甲基哌嗪

参考文献

Duffey, Matthew O.; Vos, Tricia J.; Adams, Ruth; Alley, Jennifer; Anthony, Justin; Barrett, Cynthia; Bharathan, Indu; Bowman, Douglas; Bump, Nancy J.; Chau, Ryan; Cullis, Courtney; Driscoll, Denise L.; Elder, Amy; Forsyth, Nancy; Frazer, Jonathan; Guo, Jianping; Guo, Luyi; Hyer, Marc L.; Janowick, David; Kulkarni, Bheemashankar; Lai, Su-Jen; Lasky, Kerri; Li, Gang; Li, Jing; Liao, Debra; Little, Jeremy; Peng, Bo; Qian, Mark G.; Reynolds, Dominic J.; Rezaei, Mansoureh; Scott, Margaret Porter; Sells, Todd B.; Shinde, Vaishali; Shi, Qiuju Judy; Sintchak, Michael D.; Soucy, Francois; Sprott, Kevin T.; Stroud, Stephen G.; Nestor, Michelle; Visiers, Irache; Weatherhead, Gabriel; Ye, Yingchun; Damore, Natalie
Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 197 - 208

109-01-3N-甲基哌嗪+

27008-76-0

33354-22-2

参考文献

Oenkol; Duendar; Yldrm; Erol; Sahin
Arzneimittel-Forschung/Drug Research, 2012 , vol. 62, # 12 p. 571 - 575