N-甲基哌嗪合成路线

参考文献

GLAXO GROUP LIMITED; CASILLAS, Linda, N.; CHAKRAVORTY, Subhas, J.; CHARNLEY, Adam, Kenneth; EIDAM, Patrick; HAILE, Pamela, A.; HUGHES, Terry, Vincent; JEONG, Jae, U.; KANG, Jianxing; LAKDAWALA SHAH, Ami; LEISTER, Lara, Kathryn; MARQUIS, Robert, W.; MILLER, Nathan, Andrew; PRICE, Daniel, J.; SEHON, Clark, L.; WANG, Gren, Z.; ZHANG, Daohua
Patent: WO2011/120025 A1, 2011 ;
WO 2011/120025 A1

109-01-3N-甲基哌嗪

290297-26-6奈妥吡坦

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365

109-01-3N-甲基哌嗪+

100276-65-16,7,8-三氟-1-(甲酰基甲基氨基)-1,4-二氢-4-氧代-3-喹啉羧酸乙酯

158585-86-56,8-二氟-1-(甲酰基甲基氨基)-7-(4-甲基-1-哌嗪基)-4-氧代-1,4-二氢喹啉-3-甲酸乙酯

参考文献

WO2011/61292 A1, ;

Page/Page column 43-44 ;

109-01-3N-甲基哌嗪

参考文献

Pfizer. Inc
Patent: US5892040 A1, 1999 ;

109-01-3N-甲基哌嗪+

100276-64-02,3,4,5-四氟-alpha-[(2-甲酰基-2-甲基肼基)亚甲基]-beta-氧代苯丙酸乙酯

158585-86-56,8-二氟-1-(甲酰基甲基氨基)-7-(4-甲基-1-哌嗪基)-4-氧代-1,4-二氢喹啉-3-甲酸乙酯

参考文献

Pfizer. Inc
Patent: US5892040 A1, 1999 ;

109-01-3N-甲基哌嗪

158585-86-56,8-二氟-1-(甲酰基甲基氨基)-7-(4-甲基-1-哌嗪基)-4-氧代-1,4-二氢喹啉-3-甲酸乙酯

参考文献

Pfizer. Inc
Patent: US5892040 A1, 1999 ;

109-01-3N-甲基哌嗪+

100276-65-16,7,8-三氟-1-(甲酰基甲基氨基)-1,4-二氢-4-氧代-3-喹啉羧酸乙酯

158585-86-56,8-二氟-1-(甲酰基甲基氨基)-7-(4-甲基-1-哌嗪基)-4-氧代-1,4-二氢喹啉-3-甲酸乙酯

参考文献

KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO; ZUPET, Rok; ISKRA, Jernej; RUZIC, Milos; PECAVAR, Anica; KOLENC, Ivanka; PUCELJ, Joze; PLAPER, Igor
Patent: WO2011/61292 A1, 2011 ;
Location in patent: Page/Page column 43-44 ;

109-01-3N-甲基哌嗪+

109-70-61-溴-3-氯丙烷

2031-23-41-(3-氯丙基)-4-甲基哌嗪二盐酸盐

参考文献

JOHANNES GUTENBERG-UNIVERSITAeT MAINZ; DANNHARDT, Gerd; KRAMB, Jan-Peter; PLUTIZKI, Stanislav
Patent: WO2011/73092 A1, 2011 ;
Location in patent: Page/Page column 29; 30 ;
WO 2011/073092 A1

109-01-3N-甲基哌嗪

21623-68-7

参考文献

Wu, Lixin; Lu, Meiqi; Yan, Zhihui; Tang, Xiaobin; Sun, Bo; Liu, Wei; Zhou, Honggang; Yang, Cheng
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2416 - 2426

109-01-3N-甲基哌嗪

参考文献

Pfizer Inc.
Patent: US6251904 B1, 2001 ;