N-甲基哌嗪合成路线

参考文献

NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/80980 A1, 2004 ;
Location in patent: Page 132 ;
WO 2004/080980 A1

76691-24-2(E)-3-(4-氯苯基)-2-甲基-1-(4-甲基哌嗪-1-基)丙-2-烯-1-酮

参考文献

Pratap, Ram; Gupta, R. C.; Srimal, R. C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 695 - 698

109-01-3N-甲基哌嗪+

107-04-01-溴-2-氯乙烷

参考文献

Caliendo, G.; Carlo, R. Di; Greco, G.; Meli, R.; Novellino, E.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 1 p. 77 - 84

109-01-3N-甲基哌嗪+

106-93-4二溴乙烷

77267-14-2

参考文献

Fujii; Watanabe
Ann.Rep.Tanabe pharm.Res.Chem.Abstr., 1956 , vol. 1, # 1 p. 7
Ann.Rep.Tanabe pharm.Res.Chem.Abstr., 1957 , p. 6651

109-01-3N-甲基哌嗪+

451-46-7对氟苯甲酸乙酯

773137-71-64-(4-甲基-哌嗪-1-基)-苯甲酸乙酯

参考文献

GENENTECH,INC.; FORMA TM, LLC; YUEN, Po-Wai; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; DRAGOVICH, Peter; LIU, Xiongcai; PATEL, Snahel; ZAK, Mark; ZHAO, Guiling; ZHANG, Yamin; ZHENG, Xiaozhang
Patent: WO2013/127269 A1, 2013 ;
Location in patent: Page/Page column 178 ;

109-01-3N-甲基哌嗪

77572-84-0

参考文献

Kuznetsov, V. A.; Garabadzhiu, A. V.; Ginzburg, O. F.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, p. 576 - 580
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 3 p. 637 - 642

参考文献

Agrawal, V. K.; Sharma, Satyavan; Iyer, R. N.; Chatterjee, R. K.; Sen, A. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 12 p. 1084 - 1087

109-01-3N-甲基哌嗪

77777-01-6

参考文献

Dr. Karl Thomae GmbH
Patent: US4518596 A1, 1985 ;

109-01-3N-甲基哌嗪+

329-59-9

65715-48-2

参考文献

PFIZER ITALIA S.R.L.
Patent: WO2007/99171 A2, 2007 ;
Location in patent: Page/Page column 50 ;
WO 2007/099171 A2

109-01-3N-甲基哌嗪+

39856-50-3

657410-79-2

参考文献

GILEAD CONNECTICUT, INC.; GENENTECH, INC.; BARBOSA, Antonio, J., M.; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KRISHNAMOORTHY, Ravi; KROPF, Jeffrey, E.; LEE, Seung H.; MITCHELL, Scott A.; ORTWINE, Daniel; SCHMITT, Aaron, C.; WANG, Xiaojing; XU, Jianjun; YOUNG, Wendy; ZHANG, Honglu; ZHAO, Zhongdong; ZHICHKIN, Pavel E.
Patent: WO2011/140488 A1, 2011 ;
Location in patent: Page/Page column 285; 286 ;
WO 2011/140488 A1