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Journal of the American Chemical Society, 1984 , vol. 106, # 5 p. 1323 - 1332
2-Chloro-2-methylpropane; ammonia; sodium 1) -80 deg C, 30 min, 2) Et2O, 3) Et2O, -80 deg C to RT, 8 h;
参考文献
Dervisi, Athanasia; Edwards, Peter G.; Newman, Paul D.; Tooze, Robert P.; Coles, Simon J.; Hursthouse, Michael B.
Journal of the Chemical Society - Dalton Transactions, 1998 , # 22 p. 3771 - 3776
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran; pentane T=-40°C; 0.5 h; 2: 2-amino-5-chloro-benzoic acid in tetrahydrofuran; pentane T=-40 - 0°C; 2 h; 3: With hydrogenchloride; chloro-trimethyl-silane more than 3 stages;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/9967 A2, 2005 ;
Location in patent: Page/Page column 42-43 ;
WO 2005/009967 A2
