2-甲基哌嗪合成路线

109-07-92-甲基哌嗪+

501-53-1氯甲酸苄酯

参考文献

Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 16; 20-21 ;

5866-40-0+

109-07-92-甲基哌嗪

74879-18-8(S)-(+)-2-甲基哌嗪

参考文献

Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 22-23 ;

109-07-92-甲基哌嗪

6705-31-32-吡嗪-2-基乙醇

参考文献

Kitchen; Hanson
Journal of the American Chemical Society, 1951 , vol. 73, p. 1838

109-07-92-甲基哌嗪+

108-90-7氯苯

72615-78-23-甲基-1-苯基哌嗪

参考文献

Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924

109-07-92-甲基哌嗪+

100491-29-0甲酸乙酯1-(2,4-二氟苯基)-7-氯-6-氟-4-氧代羟基吡啶[2,3-B]吡啶-3-羧酸

100491-63-21-(2,4-二氟苯基)-6-氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸乙酯

参考文献

Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369

109-07-92-甲基哌嗪+

101987-89-78-氯-1-环丙基-6,7-二氟-1,4-二氢-4-氧代-3-喹啉羧酸

101987-76-2

参考文献

Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

109-07-92-甲基哌嗪+

100491-30-37-氯-6-氟-1-(4-氟苯基)-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸乙酯

100546-84-76-氟-1-(4-氟苯基)-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸乙酯

参考文献

Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369

94242-51-01-环丙基-6,7,8-三氟-1,4-二氢-4-氧代-3-喹啉羧酸乙酯+

109-07-92-甲基哌嗪

103460-87-31-环丙基-6,8-二氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸乙酯

参考文献

Zhi, Chengxin; Long, Zheng-Yu; Manikowski, Andrzej; Comstock, Jeanne; Xu, Wei-Chu; Brown, Neal C.; Tarantino Jr., Paul M.; Holm, Karsten A.; Dix, Edward J.; Wright, George E.; Barnes, Marjorie H.; Butler, Michelle M.; Foster, Kimberly A.; LaMarr, William A.; Bachand, Benoit; Bethell, Richard; Cadilhac, Caroline; Charron, Sylvie; Lamothe, Serge; Motorina, Irina; Storer, Richard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1455 - 1465

109-07-92-甲基哌嗪

109-08-02-甲基吡嗪

参考文献

Journal of the American Chemical Society, , vol. 73, p. 1838

94695-52-01-环丙基-6,7,8-三氟-4-氧代-1,4-二氢喹啉-3-羧酸+

109-07-92-甲基哌嗪

103460-89-51-环丙基-6,8-二氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸

参考文献

Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154