反应条件
1.1: potassium hydride / tetrahydrofuran / 18 h / 20 °C / |Inert atmosphere 2.1: sodium t-butanolate; palladium 10 on activated carbon / methanol; ethyl acetate / 2 h / 20 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 3.2: 2 h / 20 °C / |Inert atmosphere 4.1: water; lithium hydroxide hydrate / ethanol / 4 h / 0 - 20 °C 4.2: pH Ca. 6.8 View Scheme
参考文献
Micale, Nicola; Ettari, Roberta; Lavecchia, Antonio; Di Giovanni, Carmen; Scarbaci, Kety; Troiano, Valeria; Grasso, Silvana; Novellino, Ettore; Schirmeister, Tanja; Zappala, Maria
European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 23 - 34