反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 180 °C / Microwave irradiation 2: water; lithium hydroxide hydrate / ethanol; tetrahydrofuran / 7 h / 0 - 20 °C 3: triethylamine; diphenyl phosphoryl azide / 3 h / 90 °C 4: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BLEICHER, Konrad; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RODRIGUEZ SARMIENTO, Rosa Maria; VIEIRA, Eric
Patent: WO2011/89132 A1, 2011 ;
WO 2011/089132 A1