N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
T=140°C; 3 h;
参考文献
Eguchi; Sasaki; Sugimoto; Ebisawa; Ishikawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 7 p. 1753 - 1759
参考文献
Dantas, T. N. de Castro; Laval, J. P.; Lattes, A.
Phosphorus and Sulfur and the Related Elements, 1982 , vol. 13, p. 97 - 106
反应条件
potassium hydroxide
1.) EtOH, 30 min; 2.) acetone, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Atassi; Briet; Berthelon; Collonges
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 5 p. 393 - 402
参考文献
Wiley; Collins
Journal of medicinal chemistry, 1969 , vol. 12, # 1 p. 146 - 149
反应条件
sodium hexamethyldisilazane in tetrahydrofuran
T=80°C; 19 h;
参考文献
Perry, Benjamin; Beevers, Rebekah; Bennett, Gavin; Buckley, George; Crabbe, Tom; Gowers, Lewis; James, Lynwen; Jenkins, Kerry; Lock, Chris; Sabin, Verity; Wright, Sara
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5299 - 5302
反应条件
sodium hydride in N,N-dimethyl-formamide
T=70 - 80°C; 1 h;
参考文献
Li, Chuen; Sammes, Michael P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2193 - 2196
反应条件
1: 2-methyl-1H-indole With sodium hydride in tetrahydrofuran; mineral oil
T=0°C;
2: 1-dimethylamino-3-chloropropane in tetrahydrofuran; mineral oil
Reflux;
参考文献
Hill, Timothy A.; Gordon, Christopher P.; McGeachie, Andrew B.; Venn-Brown, Barbara; Odell, Luke R.; Chau, Ngoc; Quan, Annie; Mariana, Anna; Sakoff, Jennette A.; Chircop, Megan; Robinson, Phillip J.; McCluskey, Adam
Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3762 - 3773
反应条件
sodium amide in benzene
参考文献
Schmidt, Diane M.; Bonvicino, Guido E.
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1664 - 1666
反应条件
sodium amide in benzene
参考文献
Schmidt, Diane M.; Bonvicino, Guido E.
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1664 - 1666
参考文献
Schmidt, Diane M.; Bonvicino, Guido E.
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1664 - 1666
