N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
参考文献
Schmidt, Diane M.; Bonvicino, Guido E.
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1664 - 1666
参考文献
Schmidt, Diane M.; Bonvicino, Guido E.
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1664 - 1666
参考文献
Iorio,M.A. et al.
Farmaco, Edizione Scientifica, 1962 , vol. 17, p. 753 - 772
反应条件
sodium amide; xylene
参考文献
Kano; Fujimoto
Pharmaceutical Bulletin, 1957 , vol. 5, p. 393,396
反应条件
diethyl ether; lithium
anschliessend Behandeln mit 2-Methoxy-thioxanthen-9-on;
参考文献
Am. Cyanamid Co.
Patent: GB834143 , 1957 ;
反应条件
sodium amide; toluene
参考文献
Yale
Journal of the American Chemical Society, 1955 , vol. 77, p. 2270
反应条件
(i) Mg, Et2O, (ii) /BRN= 1911921/; Multistep reaction;
参考文献
Pelz,K. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, # 6 p. 1880 - 1894
反应条件
(i) Mg, THF, (ii) /BRN= 2052130/; Multistep reaction;
参考文献
Pelz,K. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, # 6 p. 1880 - 1894
反应条件
1: c-octyl-Br With chloro-trimethyl-silane; magnesium; ethylene dibromide; lithium chloride; zinc dibromide in tetrahydrofuran
T=25°C; 2 h; Inert atmosphere;
2: benzenediazonium tetrafluoroborate in tetrahydrofuran
T=-60 - 25°C; Inert atmosphere;
3: 1-dimethylamino-3-chloropropane Further stages;
参考文献
Zhang, Zhi-Guang; Haag, Benjamin A.; Li, Jin-Shan; Knochel, Paul
Synthesis, 2011 , # 1 p. 23 - 29
反应条件
1: 2,3,4,5,6,7-Hexahydro-1H-cyclooctlt;bgt;indol With potassium tert-butylate; tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide
T=20°C; 2 h; Inert atmosphere;
2: 1-dimethylamino-3-chloropropane in N,N-dimethyl-formamide
T=60 - 120°C; 5.5 h; Inert atmosphere;
参考文献
Zhu, Can; Zhang, Xue; Lian, Xiongdong; Ma, Shengming
Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7817 - 7820
