N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
反应条件
potassium carbonate in propan-1-ol
Heating;
参考文献
Aiko,I.
Chemical and Pharmaceutical Bulletin, 1961 , vol. 9, p. 343 - 351
参考文献
Schmolka; Zimmer
Synthesis, 1984 , vol. NO. 1, p. 29 - 31
反应条件
sodium amide
1.) benzene, reflux, 1 h, 2.) benzene, reflux, overnight; Yield given. Multistep reaction;
参考文献
Mazzocchi; Kim
Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1473 - 1476
反应条件
sodium hydride in 1,4-dioxane
T=110°C; 0.5 h;
参考文献
Horowska, Barbara; Ledochowski, Andrzej; Dlugozima, Andrzej
Polish Journal of Chemistry, 1982 , vol. 56, # 3 p. 587 - 592
反应条件
sodium iodide; Hg; potassium carbonate in N-methyl-acetamide; hydrogenchloride; toluene
参考文献
E. R. Squibb and Sons, Inc.
Patent: US3994900 A1, 1976 ;
反应条件
1: K2CO3 / dimethylformamide / 3 h / 80 °C
2: H2, / 10percent Pd/C / ethanol
View Scheme
参考文献
Sindelar, Karel; Valenta, Vladimir; Holubek, Jiri; Matousova, Oluse; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 1 p. 282 - 295
反应条件
(i) NaNH2, toluene, (ii) /BRN= 605294/; Multistep reaction;
参考文献
Blicke,F.F. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1826 - 1831
反应条件
sodium hydroxide in chlorobenzene; toluene
4.5 h; Heating; Yield given. Yields of byproduct given;
参考文献
Ivanov, P. Yu.; Bokanov, A. I.; Budanova, L. I.; Kuzovkin, V. A.; Shvedov, V. I
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 9 p. 677 - 679
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 9 p. 1119 - 1121
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Calgon Corporation
Patent: US4044054 A1, 1977 ;
反应条件
sodium hydride in xylene
Heating;
参考文献
Guillaume, Jacques; Nedelec, Lucien; Cariou, Michel; Allais, Andre
Heterocycles, 1981 , vol. 15, # 2 p. 1227 - 1232
