N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
反应条件
1: aq. ethanol 2: LiAlH4 / diethyl ether View Scheme
参考文献
Kahovec,J.; Stamberg,J.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, p. 1838 - 1850
参考文献
Schmolka; Zimmer
Synthesis, 1984 , vol. NO. 1, p. 29 - 31
反应条件
sodium hydroxide in chlorobenzene; toluene 4.5 h; Heating; Yield given. Yields of byproduct given;
参考文献
Ivanov, P. Yu.; Bokanov, A. I.; Budanova, L. I.; Kuzovkin, V. A.; Shvedov, V. I
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 9 p. 677 - 679
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 9 p. 1119 - 1121
反应条件
1: NaNH2; xylene 2: iron-powder; acetic acid; xylene View Scheme
参考文献
Kano; Fujimoto
Pharmaceutical Bulletin, 1957 , vol. 5, p. 393,396
反应条件
(i) Mg, (ii) /BRN= 743171/, THF; Multistep reaction;
参考文献
HARMAN FINOCHEM LIMITED; JAIN, Kirti Prakash; KHAN, Afzal Yousuf; MINHAS, Gurpreet Singh; MINHAS, Harpreet Singh
Patent: WO2012/98563 A2, 2012 ;
Location in patent: Page/Page column 7 ;
反应条件
sodium hydroxide; potassium carbonate DMSO 1.) room temp., 2 h, 2.) 110 deg C, 18 h; Yield given. Multistep reaction;
参考文献
LUPIN LIMITED
Patent: WO2009/47796 A1, 2009 ;
Location in patent: Page/Page column 5 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 3 h;
参考文献
Wyatt, Paul G.; Bethell, Richard C.; Cammack, Nicholas; Charon, Daniel; Dodic, Nerina; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1657 - 1665
反应条件
in toluene 6 h; Heating;
参考文献
Sindelar, Karel; Valenta, Vladimir; Holubek, Jiri; Matousova, Oluse; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 1 p. 282 - 295
反应条件
(i) NaNH2, xylene, (ii) (basic hydrolysis); Multistep reaction;
参考文献
Craig,P.N. et al.
Journal of Organic Chemistry, 1960 , vol. 25, p. 944 - 947
反应条件
(i) Mg, EtBr, (ii) /BRN= 1873972/, (iii) aq. HCl, AcOH; Multistep reaction;
参考文献
Holm,T.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 2437 - 2443
