N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
反应条件
1: dimethylformamide 2: (i) ClSO3H, (ii) aq. NaOH View Scheme
参考文献
Kahovec,J.; Stamberg,J.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, p. 1838 - 1850
参考文献
Chan, Cecil; Yin, Hong; Garforth, Jacqui; McKie, James H.; Jaouhari, Rabih; Speers, Peter; Douglas, Kenneth T.; Rock, Peter J.; Yardley, Vanessa; Croft, Simon L.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 148 - 156
参考文献
Schmitt et al.
Bulletin de la Societe Chimique de France, 1957 , p. 1474,1480
反应条件
1.1: magnesium; I2 / tetrahydrofuran / Heating 1.2: 68 percent / tetrahydrofuran / 0 - 20 °C 2.1: 63 percent / aq. HCl / ethanol / Heating View Scheme
参考文献
Hudgens, Debjani P.; Taylor, Catherine; Batts, Timothy W.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8366 - 8378
反应条件
hydrogenchloride; 1,1-dibromo ethane; magnesium 1) THF, reflux; 2) THF, reflux;; Yield given. Multistep reaction;
参考文献
Miodownik, A.; Kreisberger, J.; Nussim, M.; Avnir, D.
Synthetic Communications, 1981 , vol. 11, # 3 p. 241 - 246
反应条件
sodium hydride in 1,4-dioxane 5 h; Heating;
参考文献
Horowska, Barbara; Ledochowski, Andrzej; Dlugozima, Andrzej
Polish Journal of Chemistry, 1982 , vol. 56, # 3 p. 587 - 592
反应条件
potassium hydroxide in dimethyl sulfoxide 6 h;
参考文献
Shanazarov, A. K.; Granik, V. G.; Andreeva, N. I.; Golovina, S. M.; Mashkovskii, M. D.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 10 p. 807 - 811
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 10 p. 1197 - 1200
反应条件
(i) Mg, THF, (ii) /BRN= 656926/; Multistep reaction;
参考文献
Galantay,E.E. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1316 - 1327
参考文献
Craig,P.N. et al.
Journal of Organic Chemistry, 1960 , vol. 25, p. 944 - 947
反应条件
iodine; magnesium in benzene 3.25 - 4.33333 h; Heating / reflux;
参考文献
NATCO PHARMA LIMITED
Patent: WO2003/101931 A2, 2003 ;
Location in patent: Page 14-15 ;
