N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
参考文献
Kyrides et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 745,746
反应条件
1: sodium amide 2: Raney nickel; ethanol View Scheme
参考文献
Biel; Di Pierro
Journal of the American Chemical Society, 1958 , vol. 80, p. 4609,4611
反应条件
in dimethyl sulfoxide
参考文献
Somin,I.N.
Zhurnal Organicheskoi Khimii, 1968 , vol. 4, # 4 p. 128 - 133,122 - 125
参考文献
Blicke,F.F. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1826 - 1831
反应条件
1: 1-dimethylamino-3-chloropropane With iodine; magnesium; ethylene dibromide in tetrahydrofuran 1 h; Inert atmosphereReflux; 2: 6,11-dihydro-11-oxo-dibenz[b,e]oxepine-2-acetic acid in tetrahydrofuran T=5 - 30°C; 3: With hydrogenchloride; acetic acid in tetrahydrofuran; water T=25 - 30°C; Product distribution / selectivity;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SATYANARAYANA, Komati
Patent: WO2011/128911 A2, 2011 ;
Location in patent: Page/Page column 22-23 ;
反应条件
1: 1-dimethylamino-3-chloropropane With ethyl bromide; magnesium in diethyl ether 2 h; Heating / reflux; 2: 6,11-dihydro-dibenz[b,e]thiepin-11-one in diethyl ether; benzene 18 h; Heating / reflux;
参考文献
SOMAXON
Patent: WO2007/136743 A2, 2007 ;
Location in patent: Page/Page column 20-21 ;
反应条件
(i) NaOMe, (ii) /BRN= 605294/; Multistep reaction;
参考文献
Ahn, Gang; Schifano-Faux, Nadege; Goossens, Jean-Francois; Baldeyrou, Brigitte; Couture, Axel; Grandclaudon, Pierre; Lansiaux, Amelie; Ryckebusch, Adina
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2259 - 2263
反应条件
sodium amide 1) benzene, 2 h, 50 deg C, 2) ether, 5 h, reflux; Yield given. Multistep reaction;
参考文献
Sindelar, Karel; Holubek, Jiri; Ryska, Miroslav; Svatek, Emil; Urban, Jiri; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 7 p. 1898 - 1909
参考文献
Tsatsas,G. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 2160 - 2162
反应条件
sodium hydroxide in ethanol
参考文献
Ekambaram,A. et al.
Journal of Organic Chemistry, 1967 , vol. 32, p. 2985 - 2987
