N,N-二甲基-1,3-二氨基丙烷合成路线 （共 206 条）
反应条件
1: diethyl ether / 2 h / Ambient temperature 2: 60 percent / triethylamine, toluenesulfonyl chloride / CH2Cl2 / 4 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 103, p. 7090
反应条件
(i) Et2O, (ii) HgO, benzene; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 84, p. 4457 - 4464
反应条件
(i), (ii) TsCl; Multistep reaction;
参考文献
Tetrahedron, , vol. 31, p. 1619 - 1622
反应条件
triethylamine in tetrahydrofuran T=50°C; 4 h;
参考文献
Galaxy Surfactants Limited
Patent: US2007/4801 A1, 2007 ;
Location in patent: Page/Page column 5 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=4°C;
参考文献
Zhu, Zheng-Jiang; Ghosh, Partha S.; Miranda, Oscar R.; Vachet, Richard W.; Rotello, Vincent M.
Journal of the American Chemical Society, 2008 , vol. 130, # 43 p. 14139 - 14143
参考文献
Thuillie,G.
Chimica Therapeutica, 1966 , vol. 1, p. 82 - 86
参考文献
Thuillier,G.; Rumpf,P.
Bulletin de la Societe Chimique de France, 1960 , p. 1786 - 1794
反应条件
1: 95 percent / NEt3 / ethanol / 24 h / Ambient temperature 2: 90 percent / H2 / 10percent Pd/C / dioxane; methanol / 760 Torr / Ambient temperature 3: 51 percent / KH2PO4, (KSO3)2NO / methanol; H2O / 4 h 4: 35 percent / 4.5 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 38 - 46
反应条件
1: 88 percent / p-toluenesulfonic acid / toluene / 5 h / Heating 2: NaBH4 / ethanol / 1 h / 20 °C View Scheme
参考文献
Akalaeva, T. V.; Bokanov, A. I.; Ivanov, P. Yu.; Nikolaeva, I. S.; Pushkina, T. V.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 3 p. 231 - 234
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 3 p. 299 - 302
反应条件
1: 56 percent / benzene / 24 h / 50 - 55 °C 2: 72 percent / acetic acid / 3 h / Heating 3: 60 percent / iron powder / acetic acid / 3 h / Heating View Scheme
参考文献
Ronsisvalle, Giuseppe; Pappalardo, Maria S.; Vittorio, Franco; Pasquinucci, Lorella; Caruso, Antonina; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 553 - 560
