N,N-二甲基-1,3-二氨基丙烷合成路线 （共 206 条）
反应条件
1: 95 percent / NEt3 / ethanol / 24 h / Ambient temperature 2: 90 percent / H2 / 10percent Pd/C / dioxane; methanol / 760 Torr / Ambient temperature 3: 51 percent / KH2PO4, (KSO3)2NO / methanol; H2O / 4 h View Scheme
参考文献
Giorgi-Renault; Renault; Gebel-Servolles; Baron; Paoletti; Cros; Bissery; Lavelle; Atassi
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 38 - 46
参考文献
Marchetti; Mattalia; Rosnati
Journal of medicinal chemistry, 1968 , vol. 11, # 5 p. 1092 - 1093
反应条件
1: Heating
2: aq. HCl, NH2OH*HCl
View Scheme
参考文献
Somin,I.N.; Kuznetsov,S.G.
Pharmaceutical Chemistry Journal, 1968 , # 8 p. 449 - 453
Khimiko-Farmatsevticheskii Zhurnal, 1968 , # 8 p. 39 - 44
参考文献
Somin,I.N.; Kuznetsov,S.G.
Pharmaceutical Chemistry Journal, 1968 , # 8 p. 449 - 453
Khimiko-Farmatsevticheskii Zhurnal, 1968 , # 8 p. 39 - 44
反应条件
(i) , (ii) NH2OH; Multistep reaction;
参考文献
Somin,I.N.; Kuznetsov,S.G.
Pharmaceutical Chemistry Journal, 1968 , # 8 p. 449 - 453
Khimiko-Farmatsevticheskii Zhurnal, 1968 , # 8 p. 39 - 44
反应条件
potassium acetate; copper diacetate in chlorobenzene
T=110°C; CH3COONa as reagent; other temper. and Cu salts;;
参考文献
Shteinberg, Ya. B.; Slavutskaya, L. M.
J. Appl. Chem. USSR (Engl. Transl.), 1983 , vol. 56, # 12 p. 2755 - 2756,2569 - 2570
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; sodium t-butanolate in toluene
T=100°C; 2.5 h;
参考文献
Dahl, Troels; Tornoe, Christian W.; Bang-Andersen, Benny; Nielsen, Poul; Jorgensen, Morten
Angewandte Chemie - International Edition, 2008 , vol. 47, # 9 p. 1726 - 1728
参考文献
Somin,I.N.
Zhurnal Organicheskoi Khimii, 1968 , vol. 4, # 4 p. 128 - 133,122 - 125
参考文献
Butler; Nordin; L'Italien; Zweisler; Poschel; Marriott
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 684 - 691
参考文献
Farbenfabr. Bayer
Patent: DE890958 , 1940 ;
