N,N-二甲基-1,3-二氨基丙烷合成路线 （共 206 条）
参考文献
Rivalle, Christian; Wendling, Francoise; Tambourin, Pierre; Lhoste, Jean-Marc; Bisagni, Emile; Chermann, Jean-Claude
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 181 - 185
反应条件
1: CHCl3 / 2 h
2: aq. HCl / ethanol / 3 h / Heating
View Scheme
参考文献
Ryczek, Jozef
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 997 - 1000
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
参考文献
Puckowska, Anna; Bielawski, Krzysztof; Bielawska, Anna; Midura-Nowaczek, Krystyna
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 1 p. 99 - 105
反应条件
in ethanol
2 h; Ambient temperature;
参考文献
Fernandez Brana; Martinez Sanz; Castellano; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 207 - 212
反应条件
1: diethyl ether / Ambient temperature
2: triethylamine, toluenesulfonyl chloride / CH2Cl2 / Heating
View Scheme
参考文献
Mock, William L.; Ochwat, Krzysztof J.
Journal of the Chemical Society. Perkin Transactions 2, 2002 , # 4 p. 843 - 847
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 0 deg C, 30 min, 2.) room temp.; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: Et3N / diethyl ether
2: aq. NaOH
View Scheme
参考文献
Bruzzese; Crescenzi
Journal of pharmaceutical sciences, 1966 , vol. 55, # 7 p. 737 - 740
反应条件
in ethanol
0.25 h; Heating; Yield given;
参考文献
Stevenson; Yen; Yang; Boykin; Wilson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1677 - 1682
反应条件
1.1: ethanol / 24 h
2.1: sodium hydroxide / water; methanol / 5 h / Reflux
2.2: 0 - 5 °C / pH 3
View Scheme
参考文献
L'OREAL; BLAISE, Christian
Patent: WO2011/154457 A1, 2011 ;
反应条件
(i) SOCl2, benzene, (ii) /BRN= 605293/, CHCl3; Multistep reaction;
参考文献
Buttini,A. et al.
Bollettino Chimico Farmaceutico, 1962 , vol. 101, p. 619 - 623
