N,N-二甲基-1,3-二氨基丙烷合成路线 （共 206 条）
反应条件
sodium hydroxide in diethyl ether
24 h; Ambient temperature;
参考文献
Chen, Yulong; White, Emil H.
Organic Preparations and Procedures International, 1996 , vol. 28, # 1 p. 65 - 76
反应条件
in toluene
T=40°C; Substitution; 0.166667 h;
参考文献
Jaszay, Zsuzsa M.; Petnehazy, Imre; Toke, Laszlo
Synthetic Communications, 1998 , vol. 28, # 15 p. 2761 - 2768
反应条件
in toluene
T=55°C; Substitution; 0.166667 h;
参考文献
Jaszay, Zsuzsa M.; Petnehazy, Imre; Toke, Laszlo
Synthetic Communications, 1998 , vol. 28, # 15 p. 2761 - 2768
参考文献
Limanov, V. E.; Epshtein, A. E.; Yakushkin, M. I.; Telegin, M. Yu.; Kotov, V. I.; et al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 2 p. 85 - 87
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 2 p. 28 - 30
反应条件
in dichloromethane; sodium hydrogencarbonate
参考文献
Sphinx Pharmaceuticals Corporation; Duke University
Patent: US5270310 A1, 1993 ;
US 5270310 A
参考文献
ISP INVESTMENTS INC.
Patent: US2006/24254 A1, 2006 ;
Location in patent: Page/Page column 2 ;
参考文献
General Aniline Corp.
Patent: DE1139738 , 1963 ;
Chem.Abstr., 1963 , vol. 58, # 11375
参考文献
Stevens,C.L. et al.
Journal of Organic Chemistry, 1965 , vol. 30, p. 3718 - 3720
反应条件
1: With benzotriazol-1-ol in dichloromethane; N,N-dimethyl-formamide
72 h;
2: in dichloromethane; N,N-dimethyl-formamide
72 h;
3: With trifluoroacetic acid
T=20°C; 168 h;
参考文献
7TM PHARMA A/S
Patent: WO2003/87044 A2, 2003 ;
Location in patent: Page/Page column 42 ;
WO 03/087044 A2
反应条件
1: pyridine; 4-(dimethylamino)pyridine / CH2Cl2
2: H2; HCl / Pd/C / methanol / pH 4
View Scheme
参考文献
Castor, Katherine J.; Liu, Zhaomin; Fakhoury, Johans; Hancock, Mark A.; Mittermaier, Anthony; Moitessier, Nicolas; Sleiman, Hanadi F.
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17836 - 17845
