N,N-二甲基-1,3-二氨基丙烷合成路线 （共 206 条）
参考文献
Koo et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5373
反应条件
triethylamine in dichloromethane T=23°C; 1 h; Inert atmosphereReflux; TimeTemperature;
参考文献
Porosa, Lukasz M.; Mistry, Kamlesh B.; Mocella, Amanda; Deng, Hellen; Hamzehi, Shayan; Caschera, Alex; Lough, Alan J.; Wolfaardt, Gideon; Foucher, Daniel A.
Journal of Materials Chemistry B, 2014 , vol. 2, # 11 p. 1509 - 1520
反应条件
phenol 1) 100 deg C, 15 min, 2) 90 deg C, 45 min; Yield given. Multistep reaction;
参考文献
Lee; Wilson; Ferry; Van Zijl; Pullen; Denny
Journal of Medicinal Chemistry, 1996 , vol. 39, # 13 p. 2508 - 2517
反应条件
in tetrahydrofuran T=65°C; 24 h;
参考文献
Jackson, Graham E.; Linder, Peter W.; Voye, Alexander
Journal of the Chemical Society - Dalton Transactions, 1996 , # 24 p. 4605 - 4612
反应条件
T=150 - 175°C; 4 - 5 h;
参考文献
Evonik Goldschmidt GmbH
Patent: US2009/54521 A1, 2009 ;
Location in patent: Page/Page column 5 ;
反应条件
1: in acetone T=-10 - 10°C; 0.75 h; 2: With mercury dichloride in acetone T=-10 - 0°C; 0.25 h; 3: With triethylamine in acetone 1 h; Heating; Further stages.;
参考文献
Park, Soobong; Hayes, Brittany L.; Marankan, Fatima; Mulhearn, Debbie C.; Wanna, Linda; Mesecar, Andrew D.; Santarsiero, Bernard D.; Johnson, Michael E.; Venton, Duane L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 6 p. 936 - 953
反应条件
sodium hydrogencarbonate in chloroform; water 1 h; Ambient temperature;
参考文献
Pouyani, Tara; Kuo, Jing-Wen; Harbison, Gerard S.; Prestwich, Glenn D.
Journal of the American Chemical Society, 1992 , vol. 114, # 15 p. 5972 - 5976
反应条件
1: 85 percent / 2-hydroxypyridine / ethane-1,2-diol / 18 h / 100 °C 2: 92 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 40 °C 3: NaHMDS / tetrahydrofuran / -40 - 20 °C 4: propan-2-ol / 18 h / 50 °C 5: aqueous hydrochloric acid / H2O / 1 h / 80 °C View Scheme
参考文献
Brambilla; Disalle; Briatico; Mantegani; Temperilli
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 421 - 426
反应条件
1: methacrylic acid methyl ester With (10H)-phenothiazine; 4-methoxy-phenol Heating / refluxNeat (no solvent); 2: With di(n-butyl)tin oxide T=70 - 101°C; Heating / refluxNeat (no solvent); 3: 2-(dimethylamino)-ethanol; 3-(dimethylamino)-n-propylamine With titanium(IV) isopropylate Product distribution / selectivity; more than 3 stages;
参考文献
Liu, Leo Zhaoqing
Patent: US2008/234515 A1, 2008 ;
Location in patent: Page/Page column 4- 5 ;
参考文献
Cyprus Foote Mineral Company
Patent: US5068368 A1, 1991 ;
