反应条件
in tetrahydrofuran under N2, dropwise addn. of BF3*Et2O to a suspension of NaBH4 in THF at 25°C with stirring, addn. of 2-ethyl-1-morpholino-1-butene after 1h, stirred for additional 3h at 25°C; slowly quenched with MeOH, addn. of NaOH, solvent evapn. (25°C, 12 Torr), alkaline aq. layer cooled to 0°C and acidified (concd. HCl), boronic acid extd.(ether), washed (H2O), dried (MgSO4), evapn.;
参考文献
Fisher, Gary B.; Juarez-Brambila, Jesus J.; Gorakki, Christian T.; Wipke, W. Todd; Singaram, Bakthan
Journal of the American Chemical Society, 1993 , vol. 115, # 2 p. 440 - 444
