1-溴-3-氯丙烷合成路线

参考文献

CALITHERA BIOSCIENCES INC.; LI, Jim; CHEN, Lijing; GOYAL, Bindu; LAIDIG, Guy; STANTON, Timothy, Friend; SJOGREN, Eric, Brian
Patent: WO2013/78123 A1, 2013 ;
Location in patent: Page/Page column 128 ;
WO 2013/078123 A1

23145-88-21-(4-氯苄基)哌嗪+

109-70-61-溴-3-氯丙烷

39577-03-2

参考文献

Buckle, Derek R.; Outred, D. James; Smith, Harry; Spicer, Barbara A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1452 - 1457

23145-88-21-(4-氯苄基)哌嗪+

109-70-61-溴-3-氯丙烷+

78-93-3丁酮

39577-03-2

参考文献

Beecham Group Limited
Patent: US4263299 A1, 1981 ;

110-00-9呋喃+

109-70-61-溴-3-氯丙烷

40517-25-7

参考文献

Naud, Sebastien; MacNaughton, Sarah J.; Dyson, Bryony S.; Woollaston, Daniel J.; Dallimore, Jonathan W. P.; Robertson, Jeremy
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 17 p. 3506 - 3518

6631-94-32-乙酰基吩噻嗪+

109-70-61-溴-3-氯丙烷

39481-55-51-[10-(3-氯丙基)吩噻嗪-2-基]乙酮

参考文献

Hulshof, Janneke W.; Vischer, Henry F.; Verheij, Mark H.P.; Fratantoni, Silvina A.; Smit, Martine J.; de Esch, Iwan J.P.; Leurs, Rob
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7213 - 7230

288-13-1吡唑+

109-70-61-溴-3-氯丙烷

405939-73-31-(3-氯丙基)-1H-吡唑

参考文献

Kuo, Gee-Hong; Prouty, Catherine; Wang, Aihua; Emanuel, Stuart; DeAngelis, Alan; Zhang, Yan; Song, Fengbin; Beall, Lawrence; Connolly, Peter J.; Karnachi, Prahba; Chen, Xin; Gruninger, Robert H.; Sechler, Jan; Fuentes-Pesquera, Angel; Middleton, Steven A.; Jolliffe, Linda; Murray, William V.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 4892 - 4909

21981-37-3+

109-70-61-溴-3-氯丙烷

405519-57-5

参考文献

FMC Corporation
Patent: US6610859 B1, 2003 ;

109-70-61-溴-3-氯丙烷+

1090-78-4

40051-12-5

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IMMUNE CONTROL, INC.
Patent: WO2008/27521 A1, 2008 ;
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371-42-6+

109-70-61-溴-3-氯丙烷