反应条件
1: 3,5-dibromo-4-hydroxypyridine With methyllithium in tetrahydrofuran; diethyl ether T=-78°C; Inert atmosphere; 2: n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=-78°C; 1.5 h; Inert atmosphere; 3: carbon dioxide in tetrahydrofuran; diethyl ether; hexane T=-78°C; 0.5 h; Inert atmosphere;
参考文献
Kyoung, Soon Kim; Zhang, Liping; Schmidt, Robert; Cai, Zhen-Wei; Wei, Donna; Williams, David K.; Lombardo, Louis J.; Trainor, George L.; Xie, Dianlin; Zhang, Yaquan; An, Yongmi; Sack, John S.; Tokarski, John S.; Darienzo, Celia; Kamath, Amrita; Marathe, Punit; Zhang, Yueping; Lippy, Jonathan; Jeyaseelan Sr., Robert; Wautlet, Barri; Henley, Benjamin; Gullo-Brown, Johnni; Manne, Veeraswamy; Hunt, John T.; Fargnoli, Joseph; Borzilleri, Robert M.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5330 - 5341
