N-甲基-2-羟基乙胺合成路线 （共 285 条）
参考文献
Modro, Tomasz A.; Graham, Douglas H.
Journal of Organic Chemistry, 1981 , vol. 46, # 9 p. 1923 - 1925
反应条件
boric acid T=180 - 230°C; 9 h;
参考文献
Barrio, Jorge R.; Petric, Andre J.; Satyamurthy, Nagichettiar; Kepe, Vladimir; Small, Gary W.
Patent: US2007/53831 A1, 2007 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 3-phenyl-2-propenoic acid With triethylamine; methyl chloroformate in dichloromethane T=20°C; 2 h; Cooling with ice; 2: 2-methylamino-ethanol in dichloromethane T=20°C;
参考文献
Guan, Li-Ping; Sui, Xin; Deng, Xian-Qing; Zhao, Dong-Hai; Qu, You-Le; Quan, Zhe-Shan
Medicinal Chemistry Research, 2011 , vol. 20, # 5 p. 601 - 606
反应条件
in benzene byproducts: C2H5OH; 1:1; azeotropic removal of C2H5OH;
参考文献
Gmelin Handbook: Sn: Org.Comp.12, 1.4.1.1.1.5.2.1.2, page 56 - 60
反应条件
1: octadecanoic acid With triethylamine; methyl chloroformate in dichloromethane T=20°C; 2 h; Cooling with ice; 2: 2-methylamino-ethanol in dichloromethane T=20°C;
参考文献
Guan, Li-Ping; Sui, Xin; Deng, Xian-Qing; Zhao, Dong-Hai; Qu, You-Le; Quan, Zhe-Shan
Medicinal Chemistry Research, 2011 , vol. 20, # 5 p. 601 - 606
反应条件
triethylamine in dichloromethane T=0 - 20°C; 20 h;
参考文献
Herold, Peter; Mah, Robert; Tschinke, Vincenzo; Behnke, Dirk; Marti, Christiane; Jotterand, Nathalie; Stutz, Stefan; Quirmbach, Michael
Patent: US2009/306064 A1, 2009 ;
Location in patent: Page/Page column 58 ;
US 20090306064 A1
反应条件
palladium diacetate; potassium carbonate; triphenylphosphine in methanol Substitution; 48 h; Heating;
参考文献
Katritzky; Yao; Denisko
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 8063 - 8065
参考文献
Aiko,I.
Chemical and Pharmaceutical Bulletin, 1961 , vol. 9, p. 343 - 351
反应条件
sodium carbonate in ethanol; water 20 h; Heating;
参考文献
Dobrev, Alexandre; Spasov, Stefan; Lattes, Armand
Journal of Chemical Research, Miniprint, 1993 , # 7 p. 1601 - 1619
反应条件
in chloroform Heating;
参考文献
Agnello,E.J.; Farina,P.R.
Journal of Medicinal Chemistry, 1972 , vol. 15, p. 363 - 365
