N-甲基-2-羟基乙胺合成路线 （共 285 条）
反应条件
1: 4,6-dichloronicotinic-3-carboxylic acid With hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide in 1,4-dioxane; dichloromethane
T=20°C; 2 h;
2: 2-methylamino-ethanol With triethylamine in dichloromethane
T=20°C; 20 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/7040 A1, 2007 ;
Location in patent: Page/Page column 50; 61 ;
WO 2007/007040 A1
反应条件
1: 3,5-difluoropyridine-2-carboxylic acid With hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide in 1,4-dioxane; dichloromethane
T=20°C; 2 h;
2: 2-methylamino-ethanol With triethylamine in dichloromethane
T=20°C; 20 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/7040 A1, 2007 ;
Location in patent: Page/Page column 65-66 ;
WO 2007/007040 A1
参考文献
Denis, Philippe; Mortreux, Andre; Petit, Francis; Buono, Gerard; Peiffer, Gilbert
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5274 - 5276
反应条件
in methanol
T=0 - 20°C;
参考文献
Tayama, Eiji; Otoyama, Seijun; Tanaka, Hiroyuki
Tetrahedron Asymmetry, 2009 , vol. 20, # 22 p. 2600 - 2608
反应条件
1: With sodium hydrogencarbonate in tetrahydrofuran
T=0 - 20°C;
2: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; Further stages.;
参考文献
Tayama, Eiji; Tanaka, Hiroyuki
Tetrahedron Letters, 2007 , vol. 48, # 24 p. 4183 - 4185
反应条件
aluminium in dichloromethane
12 h;
参考文献
Bureau, R.; Mortier, J.; Joucla, M.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 584 - 596
参考文献
Kiprianow; Raschkowan
Zhurnal Obshchei Khimii, 1937 , vol. 7, p. 1026,1029
Chem. Zentralbl., 1937 , vol. 108, # II p. 3604
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Tararov, Vitali I.; Kadyrov, Renat; Riermeier, Thomas H.; Boerner, Armin
Synthesis, 2002 , # 3 p. 375 - 380
反应条件
1: 2-methylamino-ethanol With di-tert-butyl dicarbonate in ethyl acetate
1.5 h; Ice-cooling;
2: acetic anhydride With 4-(N,N-dimethlyamino)pyridine
T=20°C; 2 h;
3: With hydrogenchloride in ethyl acetate
T=20°C; 2 h;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2003/105845 A1, 2003 ;
Location in patent: Page 63 ;
反应条件
hydrogenchloride; thionyl chloride in dichloromethane
Ambient temperature;
参考文献
University of Rochester
Patent: US5233031 A1, 1993 ;
