N-甲基-2-羟基乙胺合成路线 （共 285 条）
反应条件
T=250°C; Reaktion des Hydrochlorids;
参考文献
Ishiguro et al.
Yakugaku Zasshi, 1955 , vol. 75, p. 1318,1319,1321
Chem.Abstr., 1956 , p. 10106
反应条件
methanol; nickel T=175 - 200°C; P=40452.9 Torr; Hydrogenation;
参考文献
Sasaki
Yuki Gosei Kagaku Kyokaishi, 1958 , vol. 16, p. 614,615,617
Chem.Abstr., 1959 , p. 3234
反应条件
T=175 - 200°C; P=40452.9 Torr;
参考文献
Sasaki
Yuki Gosei Kagaku Kyokaishi, 1958 , vol. 16, p. 614,615,617
Chem.Abstr., 1959 , p. 3234
反应条件
potassium carbonate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dimethyl sulfoxide
反应条件
triethylamine in dichloromethane 18 h; Ambient temperature;
参考文献
Goff, Dane A.; Koolpe, Gary A.; Kelson, Andrew B.; Vu, Huynh M.; Taylor, Dorris L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1363 - 1368
反应条件
1.) water, 60 deg C, 20-30 h, pH 6-7; Multistep reaction;
参考文献
Chuiko, Alexey; Philonenko, Ludmila; Borisevich, Anatoly; Lozinsky, Miron
Phosphorus, Sulfur and Silicon and the Related Elements, 1996 , vol. 111, p. 66
反应条件
in acetonitrile T=20°C; Condensation;
参考文献
Methylgene, Inc.
Patent: US2007/4675 A1, 2007 ;
Location in patent: Page/Page column 92-93 ;
US 20070004675 A1
反应条件
in chloroform; ethyl acetate
参考文献
Takeda Chemical Industries, Ltd
Patent: US4962113 A1, 1990 ;
反应条件
di-tert-butyl dicarbonate in tetrahydrofuran; water T=20°C; 18 h;
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 54 ;
US 6362336 B1
反应条件
sodium hydroxide; Pd-doped copper catalyst on active carbon in water T=160°C; P=9000.9 Torr;
参考文献
Thalhammer, Franz; Gastner, Thomas
Patent: US2009/163739 A1, 2009 ;
Location in patent: Page/Page column 2-3 ;
