1: With methanesulfonyl chloride; triethylamine in dichloromethane
T=10°C; Inert atmosphere;
2: With Na2S2O3 pentahydrate in water
T=80 - 85°C; 2 - 2.5 h;
3: With 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione in water; acetic acid
T=23 - 28°C;
参考文献
GLAXO GROUP LIMITED; JIN, Qi
Patent: WO2010/102968 A1, 2010 ;
Location in patent: Page/Page column 39 ;
