反应条件
1: 2,6-dichloropyrazine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran T=-78°C; 2: formic acid ethyl ester in tetrahydrofuran T=-78°C; 2 h;
参考文献
PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler
Patent: WO2010/16005 A1, 2010 ;
Location in patent: Page/Page column 111-112 ;
WO 2010/016005 A1