1-甲基-4-硝基咪唑-2-羧酸乙酯合成路线 （共 11 条）
反应条件
sulfuric acid; nitric acid T=0 - 20°C; 1.5 h; Heating / reflux;
参考文献
UNIVERSITY OF WESTERN SYDNEY
Patent: WO2005/33077 A1, 2005 ;
Location in patent: Page/Page column 53-54 ;
反应条件
potassium carbonate in acetone T=60°C; 4 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2006/89664 A2, 2006 ;
Location in patent: Page/Page column 14; 29; 30 ;
参考文献
Wurtz, Nicholas R.; Turner, James M.; Baird, Eldon E.; Dervan, Peter B.
Organic Letters, 2001 , vol. 3, # 8 p. 1201 - 1203
反应条件
sulfuric acid; nitric acid T=95°C; 0.833333 h;
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3493 - 3501
反应条件
1: 56 percent / nitric acid; sulfuric acid / acetic anhydride / 12 h / -40 °C 2: 95 percent / ethanol View Scheme
参考文献
Organic Letters, , vol. 3, # 8 p. 1201 - 1203
反应条件
sodium hydride 0.5 h; Ambient temperature;
参考文献
Nishiwaki, Eiji; Tanaka, Shigeaki; Lee, Hideaki; Shibuya, Masayuki
Heterocycles, 1988 , vol. 27, # 8 p. 1945 - 1952
反应条件
1: 95 percent / NaOH / H2O / 0.25 h / Heating 2: oxalyl chloride / acetonitrile; CHCl3 / Heating View Scheme
参考文献
Krowicki, Krzysztof; Lown, J. William
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3493 - 3501
反应条件
1: 99 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature 2: 94 percent / Et3N / acetonitrile; diethyl ether / 1.) 40 deg C, 10 min, 2.) RT, 25 h, 3.) 40 deg C, 4 h View Scheme
参考文献
Grehn, Leif; Ding, Lu; Ragnarsson, Ulf
Acta Chemica Scandinavica, 1990 , vol. 44, # 1 p. 67 - 74
反应条件
1: 99 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature 2: 94 percent / Et3N / acetonitrile; diethyl ether / 1.) 40 deg C, 10 min, 2.) RT, 25 h, 3.) 40 deg C, 4 h 3: 94 percent / aq. NaOH / 1.) 60 deg C, 15 min, 2.) RT, 1 h View Scheme
参考文献
Grehn, Leif; Ding, Lu; Ragnarsson, Ulf
Acta Chemica Scandinavica, 1990 , vol. 44, # 1 p. 67 - 74
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 5 h; Ambient temperature;
参考文献
BAYER HEALTHCARE AG
Patent: WO2006/89664 A2, 2006 ;
Location in patent: Page/Page column 14; 30 ;
