2-氯甲基-4-甲基喹唑啉合成路线 (共 4 条)
反应条件
1: 2-amino acetophenone With hydrogenchloride in 1,4-dioxane T=-10 - 25°C; 2: chloroacetonitrile in 1,4-dioxane T=-10 - 2°C; 3 h; 3: With sodium hydroxide in 1,4-dioxane; water T=5 - 11°C;
参考文献
WO2006/48427 A1, ;
Page/Page column 9 ;
反应条件
phosphorus trichoride in chloroform Heating / reflux;
参考文献
WO2005/51950 A1, ;
Page/Page column 20 ;
反应条件
trichlorophosphate 0.5 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 23, # 4 p. 1263 - 1264
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one T=75°C; 6 h;
参考文献
WO2005/51950 A1, ;
Page/Page column 18 ;