2-三氟甲基咪唑并[1,2-A]吡嗪合成路线 （共 2 条）
反应条件
in ethanol T=20°C; 48 h; Reflux;
参考文献
ARES TRADING S.A.; JORAND-LEBRUN, Catherine; SWINNEN, Dominique; GERBER, Patrick; KULKARNI, Santosh
Patent: WO2012/130915 A1, 2012 ;
Location in patent: Page/Page column 74 ;
WO 2012/130915 A1
反应条件
1: 2-amino-pyrazine; 3-bromo-1,1,1-trifluoroacetone in ethanol 42 h; Heating / reflux; 2: sodium hydrogencarbonate in water pH=8;
参考文献
WO2004/29051 A1, ;
Page 43-44 ;
WO 2004/029051 A1
