(3-三氟甲基苯基)-氨基甲酸叔丁酯合成路线 （共 3 条）
参考文献
Stec, Markian M.; Bo, Yunxin; Chakrabarti, Partha P.; Liao, Lillian; Ncube, Mqhele; Tamayo, Nuria; Tamir, Rami; Gavva, Narender R.; Treanor, James J.S.; Norman, Mark H.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5118 - 5122
参考文献
Cordi, Alex A; Desos, Patrice; Ruano, Elisabeth; Al-Badri, Hashim; Fugier, Claude; Chapman, Astrid G; Meldrum, Brian S; Thomas, Jean-Yves; Roger, Anita; Lestage, Pierre
Farmaco (Societa chimica italiana : 1989), 2002 , vol. 57, # 10 p. 787 - 802
反应条件
1.1: s-BuLi / cyclohexane; hexane; tetrahydrofuran / 3 h / -40 °C
1.2: 87 percent / cyclohexane; hexane; tetrahydrofuran / 1 h / -78 °C
2.1: 96 percent / aq. HCl / tetrahydrofuran / 6 h / Heating
3.1: NaH / tetrahydrofuran / 1 h / 0 °C
3.2: 81 percent / tetrahydrofuran / 4 h / -20 - 20 °C
4.1: 76 percent / Et3SiH; TFA / 48 h / 110 - 120 °C
5.1: 80 percent / EtMgBr / tetrahydrofuran / 3 h / 20 °C
6.1: N-fluorobenzenesulfonimide; [Pd2((S)-DM-BINAP)2(μ-OH)2](2+)*2TfO(1-) / acetone / 18 h / 0 °C
7.1: TFA / CH2Cl2 / 8 h / 20 °C
View Scheme
参考文献
Zoute, Ludivine; Audouard, Christophe; Plaquevent, Jean-Christophe; Cahard, Dominique
Organic and biomolecular chemistry, 2003 , vol. 1, # 11 p. 1833 - 1834
