5-甲氧基-3-二氢色原酮合成路线 （共 9 条）
反应条件
1: With diphenylphosphoranyl azide; triethylamine in dichloromethane; toluene T=60 - 85°C; 1.63 h; Heating / reflux; 2: With hydrogenchloride in dichloromethane; water; toluene 2 h; Heating / reflux;
参考文献
WYETH
Patent: WO2005/12291 A1, 2005 ;
Location in patent: Page/Page column 75 ;
WO 2005/012291 A1
反应条件
hydrogenchloride; triethylamine in dichloromethane; toluene
反应条件
pyridine; chromium(VI) oxide; acetic anhydride in dichloromethane 0.166667 h;
参考文献
The Upjohn Company
Patent: US5306830 A1, 1994 ;
US 5306830 A
反应条件
1: 93 percent / K2CO3 / acetonitrile / 1 h / Heating 2: 24 percent / thallium(III) sulfate / H2O / 21.5 h / 60 °C 3: 90 percent / H2, NaOH / Pd/C / ethanol / 16 h / 2662.7 Torr 4: 62 percent / pyridine, CrO3, acetic anhydride / CH2Cl2 / 0.17 h View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 44, # 10 p. 1024 - 1028
反应条件
1: 24 percent / thallium(III) sulfate / H2O / 21.5 h / 60 °C 2: 90 percent / H2, NaOH / Pd/C / ethanol / 16 h / 2662.7 Torr 3: 62 percent / pyridine, CrO3, acetic anhydride / CH2Cl2 / 0.17 h View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 44, # 10 p. 1024 - 1028
反应条件
1: 90 percent / H2, NaOH / Pd/C / ethanol / 16 h / 2662.7 Torr 2: 62 percent / pyridine, CrO3, acetic anhydride / CH2Cl2 / 0.17 h View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 44, # 10 p. 1024 - 1028
反应条件
3,5-bis(ethoxycarbonyl)-2,6-diethylpyridine 1-oxide; Me4tBuXPhosAuNTf2 in 1,2-dichloro-ethane T=20°C; regioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 8 p. 1915 - 1918
反应条件
1: 8 percent / thallium(III) sulfate / H2O / 28 h / 60 °C 2: 62 percent / pyridine, CrO3, acetic anhydride / CH2Cl2 / 0.17 h View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 44, # 10 p. 1024 - 1028
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: 3,5-bis(ethoxycarbonyl)-2,6-diethylpyridine 1-oxide; Me4tBuXPhosAuNTf2 / 1,2-dichloro-ethane / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 8 p. 1915 - 1918
