N-Boc-L-2-环己基甘氨酸合成路线 （共 13 条）
反应条件
1: 30 percent / HOBt; EDCl / tetrahydrofuran 2: HCl / dioxane; tetrahydrofuran 3: HOBt; EDCl 4: 100 percent / aq. NaOH / methanol 5: 100 percent / HOAt; DCC / CH2Cl2; tetrahydrofuran 6: 100 percent / aq. NaOH View Scheme
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1: NEt3 / tetrahydrofuran / -10 °C 2: 66 percent / NaBH4 / H2O / 0 °C View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 14, # 1 p. 275 - 278
反应条件
1: dichloromethane / 0.5 h / 0 °C
2: sodium hydroxide / water / 2 h / 0 °C
View Scheme
参考文献
MEDIVIR UK LIMITED; AYESA, Susana; CARLQUIST, Peter; ERSMARK, Karolina; GRABOWSKA, Urszula; HEWITT, Ellen; JOeNSSON, Daniel; KAHNBERG, Pia; KLASSON, Bjoern; LIND, Peter; ODEN, Lourdes; PARKES, Kevin; WIKTELIUS, Daniel
Patent: WO2011/70541 A1, 2011 ;
