1-甲基-3-吲唑羧酸甲酯合成路线 （共 12 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=50°C; 18 h;
参考文献
Affinium Pharmaceuticals, Inc.
Patent: US6730684 B1, 2004 ;
Location in patent: Page column 18 ;
反应条件
potassium carbonate in water; ethyl acetate
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US5955470 A1, 1999 ;
US 5955470 A
反应条件
sulfuric acid 4 h; Reflux;
参考文献
Ali, Nasir Ali Shafakat; Zakir, Shaikh; Patel, Muqtadir; Farooqui, Mazahar
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 39 - 43
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1535 - 1537
反应条件
copper quinolate in water; dimethyl sulfoxide T=120°C; 24 h;
参考文献
Zhu, Yan; Yan, Hong; Lu, Linhua; Liu, Defu; Rong, Guangwei; Mao, Jincheng
Journal of Organic Chemistry, 2013 , vol. 78, # 19 p. 9898 - 9905
参考文献
Chemische Berichte, , vol. 52, p. 1345,1348
参考文献
Chemische Berichte, , vol. 52, p. 1345,1348
反应条件
1: 100 percent / 1N NaOH / tetrahydrofuran / Ambient temperature 2: SOCl2 / CHCl3 / Heating View Scheme
参考文献
Fludzinski; Evrard; Bloomquist; Lacefield; Pfeifer; Jones; Deeter; Cohen
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1535 - 1537
反应条件
sodium hydroxide in tetrahydrofuran Ambient temperature;
参考文献
Fludzinski; Evrard; Bloomquist; Lacefield; Pfeifer; Jones; Deeter; Cohen
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1535 - 1537
反应条件
in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
Reddy, E. Vishnu Vardhan; Ramanatham; Devanna; Srinivasa Reddy; Rajender
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # SUPPL.1 p. E221-E227
